Endocrine Abstracts

The central obese phenotype characteristic of Cushing's syndrome emphasises the role of glucocorticoids (GC) in regulating adipose tissue mass and distribution. We have shown that GCs stimulate adipocyte differentiation, but equally inhibit adipose stromal cell (ASC) proliferation. These effects are regulated at a pre-receptor level through 11beta-hydroxysteroid dehydrogenase type 1, but the 'post-receptor' signalling pathways remain unclear. To define novel GC targets in huma...

Background: Most patients responding to injectable somatostatin receptor ligands exhibit IGF-I variability around the upper limit of normal (ULN) during long-term follow up. These fluctuations are thought to result from assay variability, nutrition, comorbid conditions, concomitant medications and other unknown factors. The magnitude and factors affecting this variability arenot well understood in patients with acromegaly treated with injectable SRLs.Met...

Purpose: The efficacy and safety of RAD, an mTOR inhibitor, in patients with well differentiated metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NET).Material and methods: We studied seven male patients (mean age 55 years, range 36–75) with well differentiated non functioning stage IV GEP-NETs (five pancreatic, one hindgut carcinoid, and one NET of unknown primary). All received RAD 10 mg/day in combination with long acting octerotide 3...

Introduction: After progression on conventional treatment options, some patients with advanced ACC are offered experimental Phase I therapies. The outcomes of these patients have not yet been formally evaluated. This study aims to describe the experience of refractory ACC patients treated on Phase I clinical trials at the RMH.Methods: We retrospectively reviewed the records of metastatic ACC patients consecutively treated in our Drug Development Unit bet...

Background: People who have autoimmune atrophic gastritis commonly develop type 1 gNETs, but are also at increased risk of developing gastric adenocarcinoma. Type I gNET patients usually have multiple gastric polyps and have an excellent prognosis when the polyps measure.Method: Retrospective audit of type I gNET patients managed within Liverpool ENETS Centre of Excellence 2004–2018.Results: 86 patients (median age 67 years, 5...

Congenital hypothyroidism (CH) is the most frequent endocrine congenital defect affecting about 1:3000 newborns. In economically/ socially advanced counties, CH is routinely screened by means of TSH (and/or T4) measurement on dry blood spot (dbs) since more than 20 years. Neonatal screening allows early recognition and treatment of affected newborns. Upon data collected in years <2000 by the Italian CH Registry, the newborns with confirmed CH and gland-in-situ constituted ...

Background: Visceral obesity has been associated with systemic oxidative stress, measured by oxidized LDL (oxLDL).Aim: Investigate circulating oxLDL levels in patients with visceral obesity, and its relationship with metabolic abnormalities found in visceral obesity.Methods: We evaluated blood pressure (BP), waist circumference (WC), fasting glucose, total cholesterol, LDL, HDL, triglycerides, ApoA1, ApoB, ApoCIII, Lp(a) and oxLDL ...

Background: To determine whether radioiodine remnant ablation (RRA) reduces cause-specific mortality (CSM) or tumor recurrence (TR) rates after bilateral thyroidectomy (BT) in low-risk adult papillary thyroid carcinoma (APTC) patients treated with curative intent, we compared outcome in 1836 stage I patients having BT alone with 832 having BT+RRA.Methods: THEN cohort (1966-1990) comprised 809 patients; 36% having RRA within 6 postoperative months. NOW co...

IL17 proinflammatory cytokine through T cell activation has prominent bone-wasting effect. Our previous results highlighted the role of IL17 in postmenopausal osteoporosis. To demonstrate the HLA allele association with the increased IL17 levels in postmenopausal osteoporosis was the object of the study.HLA class I and II alleles were measured in 64 postmenopausal women (in four subgroups: with low IL17 (1, 3) and high (>3.04 pmol/l) IL17 levels (2, ...

Introduction: Dysregulation of the insulin-like Growth Factor (IGF) system and particularly IGF-I and IGF binding protein-1 (IGFBP-1) has been implicated in the pathogenesis of obesity, diabetes mellitus and its complications such as cardiovascular disease and nephropathy, but relatively little is known about the genomics of the IGF system in health and disease.Methods: Six single nucleotide polymorphisms (SNPs) were genotyped in the IGFBP-1 gene, in a r...